Unlocking Healing: The Power of Platelets in High-Dose PRP Injections

At Regenesis Stem Cell Center, we're passionate about harnessing your body's natural repair mechanisms. One of our advanced therapies involves high-dose platelet-rich plasma (PRP) injections, which typically deliver 10 billion or more platelets directly to injured areas, such as joints. But what exactly do these platelets do? Let's break it down.

Key Functions of Platelets in PRP:

Platelets are the MVPs of tissue regeneration. Concentrated from your own blood, they:

• Stop bleeding and form clots (hemostasis).
• Modulate inflammation to reduce pain and swelling.
• Stimulate cell growth and migration for faster healing.
• Remodel extracellular matrix to rebuild stronger tissues.

This is ideal for conditions such as osteoarthritis, tendinopathies, or ligament injuries, amplifying your body's natural repair signals.

Granule Release Timeline:

Upon injection and activation (by tissue contact or activators), platelets release bioactive molecules from their granules:

• First Hour: Approximately 95% of stored growth factors are released, with 70% occurring within the initial 10 minutes—kickstarting immediate repair, such as attracting healing cells.
• Next 7-10 Days: Platelets synthesize and secrete more factors until they naturally expire around day 8, sustaining long-term regeneration.

Growth Factors at Work:

These powerhouse molecules drive healing:

• PDGF: Platelet-derived GF boosts cell proliferation and new blood vessel growth.
• TGF-β: Tissue-derived GF-Beta enhances matrix production and immune balance.
• VEGF: Vascular endothelial GF improves blood flow for nutrient delivery.
• EGF: Epithelial GF speeds up skin and tissue cell growth.
• FGF: Fibroblast GF supports cartilage and bone repair.
• IGF: Insulin-like GF promotes protein synthesis and cell survival.

Clotting Cascade and Gelling in Joints:

Activated platelets trigger clotting: They aggregate, release fibrinogen, and convert it to a fibrin gel. This creates a natural scaffold at the injection site (e.g., your knee joint), trapping growth factors for prolonged action, reducing inflammation, and aiding cartilage repair. It's like building a temporary "healing hub" right where you need it!

Ready to experience the regenerative edge? Contact us at Regenesis Stem Cell Center to learn if high-dose PRP is right for you.